Cancer and radiations

Cancer and radiations

This group’s work focuses on epidemiology of cancers and, more specifically, on the epidemiology of the effects of ionising radiation; the long-term iatrogenic effects of treatment of cancer and the outlook for patients treated for cancer or tumours.

Lire la suite

For several years, the group has been setting up and following cohorts of subjects exposed to very variable doses of ionising radiation. These include cohort ANGIO (a cohort of children treated with radiotherapy for haemangioma), cohort TOMENF (a cohort of children exposed to CT scans), VENUS (a cohort of patients treated for thyroid cancer), SURVSEIN (a cohort of women treated for breast cancer), TRAVNUCL (a cohort of employees of companies contracted to the French nuclear industry). The team is also involved in case-control studies: on the risk of thyroid cancer in Cuba, on thyroid cancer in French Polynesia and on risk factors for differentiated thyroid cancer in young subjects in Eastern France The group’s main cohort is that of the French Childhood Cancer Survivors Study (FCCSS), a national cohort of 20,000 subjects treated before the year 2000 for childhood cancer. The FCCSS is the continuation of the French contingent of the EURO2K historic cohort and is a component of the Hope-épi (Programme of Investment in the Future) project. The role of radiotherapy and chemotherapy on the outlook for children treated for solid tumours is explored by sending a self-administered questionnaire, the establishment of follow-up visits and estimation of the doses administered during radiotherapy both within and at a distance from the irradiation fields. BIOF is the biological tissue bank which consists of samples of saliva and blood taken from survivors in the FCCSS. The BIOF is to be used for a study of the genetic factors which might predispose to the development of iatrogenic disease in some patients treated for childhood cancer because of their increased susceptibility to anti-cancer therapies. In parallel, the group is developing software to be used to simulate radiotherapy and estimate the doses administered during this radiotherapy both within and at a distance from the irradiation fields. The study of the outcome for subjects treated for cancer, in particular in childhood, has become the principal research project of the team over the last five years. Prospects Our main short-term project is to complete work on the FCCSS national cohort of children cured of childhood cancer and its associated BIOF tissue bank. In addition, we are going to use data from the SNIIR-AM to continue to study the medical outcome in this cohort. We also intend to continue the analysis of the various cohorts we have established and to complete the work on the new specific software to estimate irradiation doses at a distance from external beam radiotherapy and validate it clinically.

Responsable(s)
Florent
DE VATHAIRE
Responsable d'équipe
Nadia
HADDY
Co-responsable d'équipe
Localisation

Hôpital Gustave Roussy, Bat. B2M

114 rue Edouard Vaillant
94805 Villejuif


Principaux Financeurs
Inserm
Programme Investissement d’Avenir
ARC
INCA
Collaborations/Partenaires
EDF

Membres

Rodrigue
ALLODJI
Biostatisticien
AMEL
BELHOUT
Assistant d'étude clinique
Amel
BOUMARAF
Assistant d'étude clinique
Florent
DE VATHAIRE
Responsable d'équipe
Charlotte
DEMOOR- GOLDSCHMIDT
Epidémiologiste
Brice
FRESNEAU
Epidémiologiste
Alfred Arnaud
GBETCHEDJI
Epidémiologiste
Nadia
HADDY
Co-responsable d'équipe
Catherine
HILL
Epidémiologiste
Neige
JOURNY
Epidémiologiste
Isao
KOBAYASHI
Gestionnaire base de données
Martine
LABBE
Attaché de recherche clinique
Imene
MANSOURI
Epidémiologiste
Aude
MITTON
Chef de projet
Carole
RUBINO
Epidémiologiste
Vincent
SOUCHARD
Data Manager
Cécile
TEINTURIER
Epidémiologiste
Thi Van Trinh
TRAN
Epidémiologiste
Cristina
VERES
Physicien
Giao
VU-BEZIN
Chef de projet
Monia
ZIDANE
Epidémiologiste

Dernières publications

Using decision fusion methods to improve outbreak detection in disease surveillance. Texier, Gaëtan; Alldoji, Rodrigue S.; Diop, Loty; Meynard, Jean-Baptiste; Pellegrin, Liliane; Chaudet, Hervé. BMC Medical Informatics and Decision Making. 2019; : . doi:10.1186/s12911-019-0774-3
Article
Volume effects of radiotherapy on the risk of second primary cancers: A systematic review of clinical and epidemiological studies. Journy, Neige; Mansouri, Imène; Allodji, Rodrigue S.; Demoor-Goldschmidt, Charlotte; Ghazi, Debiche; Haddy, Nadia; Rubino, Carole; Veres, Cristina; Zrafi, Wael Salem; Rivera, Sofia; Diallo, Ibrahima; De Vathaire, Florent. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology. 2019; 150-159: p.150-159. doi:10.1016/j.radonc.2018.09.017
Article
Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk. Zidane, Monia; Ren, Yen; Xhaard, Constance; Leufroy, Axelle; Côte, Suzanne; Dewailly, Eric; Noël, Laurent; Guérin, Thierry; Bouisset, Patrick; Bernagout, Solène; Paaoafaite, John; Iltis, Jacques; Taquet, Marc; Suhas, Eric; Rachédi, Frédérique; Boissin, Jean Louis; Sebbag, Joseph; Shan, Larrys; Bost-Bezeaud, Frédérique; Petitdidier, Patrice; Rubino, Carole; Gardon, Jacques; de Vathaire, Florent. Asian Pacific journal of cancer prevention: APJCP. 2019; 355-367: p.355-367. doi:10.31557/APJCP.2019.20.2.355
Article
Reiterative Radiofrequency Ablation in the Management of Pediatric Patients with Hepatoblastoma Metastases to the Lung, Liver, or Bone. Yevich, Steven; Calandri, Marco; Gravel, Guillaume; Fresneau, Brice; Brugières, Laurence; Valteau-Couanet, Dominique; Branchereau, Sophie; Chardot, Christophe; Aerts, Isabelle; de Baere, Thierry; Tselikas, Lambros; Deschamps, Frederic. Cardiovascular and Interventional Radiology. 2019; 41-47: p.41-47. doi:10.1007/s00270-018-2097-7
Article
Cumulative Radiation Exposures from CT Screening and Surveillance Strategies for von Hippel-Lindau-associated Solid Pancreatic Tumors. Tirosh, Amit; Journy, Neige; Folio, Les R.; Lee, Choonsik; Leite, Christiane; Yao, Jianhua; Kovacs, William; Linehan, W. Marston; Malayeri, Ashkan; Kebebew, Electron; Berrington de González, Amy. Radiology. 2019; 116-124: p.116-124. doi:10.1148/radiol.2018180687
Article

Thèses

Association entre dysfonction thyroïdienne et risque de cancers du sein et de la thyroïde chez la femme adulte. Tran, Thi Van Trinh. []: Université Paris Saclay; 2018.
Thesis
Etude épidémiologique chez les travailleurs exposés aux rayonnements ionisants dans les centres d’imagerie médicale du sud du Benin. GBETCHEDJI, Alfred Arnaud. []: Université Paris Saclay/Université d’Abomey-Calavi; 2018.
Thesis
Etude dosimétrique et modélisation des composantes de la dose à distance pour les faisceaux d'électrons en radiothérapie externe. Alabdoaburas Mohamad Mohamad. []: Paris Saclay; 2017.
Thesis
Complications rénales chroniques à long termes chez les survivants de cancer. Mansouri Imène. []: Paris Sud; 2016.
Thesis
Modélisation flexible du risque d'événements iatrogènes radio-induits. Benadjaoud, Mohamed Amine. []: Paris XI; 2015.
Thesis
L’apport alimentaire en iode, sélénium dans les ongles, et risque du cancer différencié de la thyroïde : analyses d’études cas-témoins du consortium Epi-Thyr. Ren Yan. []: Paris Saclay; 2015.
Thesis
Optimisation et validation des méthodes de calcul de dose à distance des faisceaux d’irradiation pour leur application dans les études épidémiologiques et cliniques en radiothérapie. Jérémi Vũ Bezin. []: Paris Saclay; 2015.
Thesis
Anthropométrie, alimentation et risque du cancer différencié de la thyroïde dans les îles du Pacifique. Cléro Enora. []: Paris XI; 2012.
Thesis
Analyses pronostiques en oncologie pédiatrique : Identification de facteurs de susceptibilité tumorale ou individuelle à l’efficacité et/ou à la toxicité des traitements anticancéreux utilisés chez l’enfant. Fresneau Brice. []: Paris Sud; .
Thesis
La susceptibilité génétique au cancer de la thyroïde après irradiation dans l’enfance. Zidane Monia. []: Paris Sud; .
Thesis